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NORPHENAZONE

3-Methyl-1-phenyl-2-pyrazolin-5-one; Norantipyrine; 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; Phenylmethylpyrazolone; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 3-methyl-1-phenyl-5-pyrazolone; C.I. developer 1; developer z; 1-phenyl-3-methylpyrazolone-5; 1-Fenyl-3-methyl-2-pyrazolin-5-on; 1-Phenyl-3-methylpyrazolone-5;

CAS NO:

89-25-8

  • Türü                : Organik
  • Formülü          : C10H10N2O
  • EINECS NO.  : 201-891-0
  • Mol Agırlığı    : 174.20
  • H.S. CODE     : 2933.19
  • Zehililik          : Oral rat LD50: 1915 mg/kg
  • Türevleri        :
  • Kütlesi           :
  • Ekleyen          : Kimyahane Editr

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE light yellow crystalline powder
MELTING POINT 129 -130 C
BOILING POINT Decomposes
SPECIFIC GRAVITY  

SOLVENT SOLUBILITY

 
SOLUBILITY IN WATER Soluble in hot water

PRINTING RESISTANCE

 
SOLVENT RESISTANCE  
pH  
VAPOR DENSITY  
AUTOIGNITION  
NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

stable under ordinary conditions. Light sensitive

APPLICATIONS

Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders. The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine. Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. Norphenazone possibly can be used in the synthesis of drugs (antipyretic and analgesic medicines), dyes, pesticides and other organic compounds. The prefix "nor-" describes normal structure which has no branched chain of carbon atoms. In case of norphenazone, it has one less methylene group than its homologue, antipyrine. Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone.

SALES SPECIFICATION

APPEARANCE

light yellow crystalline powder

ASSAY

99.0% min

MELTING POINT

129 -130 C

PURITY

 

MOISTURE

 

IDENTIFICATION

 

HCl INSOLUBLES

 

WATER

 
SULFATE  

CONTENT

 

IMPURITY

 

LOSS ON DRYING

0.5% max

HEAVY METALS

 
Pb  

Zn

 

CHLORIDE

 

RESIDUE ON IGNITION

 
TRANSPORTATION
PACKING
25kgs in bag
HAZARD CLASS not regulated
UN NO.  
REMARKS Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25
OTHER INFORMATION  
 

 

 

 

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